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Enantioselective Oxidative Cross‐Coupling Reaction of 3‐Indolylmethyl CH Bonds with 1,3‐Dicarbonyls Using a Chiral Lewis Acid‐Bonded Nucleophile to Control Stereochemistry

2010; Wiley; Volume: 49; Issue: 32 Linguagem: Inglês

10.1002/anie.201002108

1521-3773

Chang Guo, Jin Song, Shi‐Wei Luo, Liu‐Zhu Gong,

Axial and Atropisomeric Chirality Synthesis

A highly enantioselective CH-activation-based oxidative coupling reaction of 3-arylmethylindole derivatives with dibenzyl malonate by using chiral Lewis acid bonded nucleophiles provided an approach to indole derivatives (see scheme; DDQ=2,3-dichloro-5,6-dicyano-1,4-benzoquinone, OTf=trifluoromethanesulfonate). Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.