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Extensive Immunoglobulin Binding of Plasmodium falciparum -Infected Erythrocytes in a Group of Children with Moderate Anemia

1998; American Society for Microbiology; Volume: 66; Issue: 1 Linguagem: Inglês

10.1128/iai.66.1.361-363.1998

1098-5522

Carin Scholander, Johan E. Carlson, Peter G. Kremsner, Mats Wahlgren,

Vector-borne infectious diseases

ABSTRACT Immunoglobulins (Ig) from healthy, nonimmune individuals bind to the surfaces of Plasmodium falciparum -infected erythrocytes (RBC). In order to investigate the presence of this parasite phenotype in wild isolates and its potential association with malarial anemia, we conducted a study of 207 anemic or nonanemic children with malaria in Gabon. Surface Ig binding to infected RBC was detected for 83% of the isolates. No difference in Ig binding between the groups was observed, but all isolates which exhibited extensive Ig binding were found in a group of moderately anemic children.