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Response to Depression and Blood Pressure Control: All Antidepressants Are not the Same

2009; Lippincott Williams & Wilkins; Volume: 54; Issue: 1 Linguagem: Inglês

10.1161/hypertensionaha.109.133512

1524-4563

Carmilla M.M. Licht, Brenda W.J.H. Penninx, Eco J. C. de Geus,

Heart Rate Variability and Autonomic Control

HomeHypertensionVol. 54, No. 1Response to Depression and Blood Pressure Control: All Antidepressants Are not the Same Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBResponse to Depression and Blood Pressure Control: All Antidepressants Are not the Same Carmilla M.M. Licht Brenda W.J.H. Penninx Eco J.C. de Geus Carmilla M.M. LichtCarmilla M.M. Licht VU University Medical Center, Department of Psychiatry, EMGO Institute and Neurocampus, Amsterdam, Amsterdam, The Netherlands Brenda W.J.H. PenninxBrenda W.J.H. Penninx VU University Medical Center, Department of Psychiatry, EMGO Institute for Health and Care Research (EMGO) and Neurocampus, Amsterdam, Amsterdam, The Netherlands, Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands Eco J.C. de GeusEco J.C. de Geus VU University Medical Center, Department of Psychiatry, EMGO Institute for Health and Care Research (EMGO) and Neurocampus, Amsterdam, Amsterdam, The Netherlands, VU University, Department of Biological Psychology, Amsterdam, The Netherlands Originally published18 May 2009https://doi.org/10.1161/HYPERTENSIONAHA.109.133512Hypertension. 2009;54:e2Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: May 18, 2009: Previous Version 1 In their response to our report on blood pressure in the Netherlands Study of Depression and Anxiety and Depression, Dawood et al1 make the important observation that the cardiovascular effects of serotonin-specific reuptake inhibitor treatment in depressed patients are partly different from those of other antidepressants. Although users of all antidepressants have lower heart rate variability,2,3 only users of nonadrenergic and serotonergic working antidepressants and tricyclic antidepressants show a parallel increase in blood pressure. We can add a further congruent data point to this: users of serotonin-specific reuptake inhibitors have a lower heart rate than unmedicated patients, whereas users of tricyclic antidepressants and NS working antidepressants clearly have a higher heart rate.3 There is an attractive, testable explanation for this pattern of findings, which is suggested by the work quoted by Dawood et al.4 Serotonin-specific reuptake inhibitors may decrease vagal tone but, in parallel, decrease sympathetic tone, at least in part of the subjects. This would act to keep heart rate and blood pressure intact even in the presence of decreased vagal tone. To test this hypothesis further, we are currently engaged in analyses that seek to relate the pre-ejection period, a measure of cardiac sympathetic control,5 with the psychopathology and medication status of the Netherlands Study of Depression and Anxiety and Depression participants.DisclosuresNone.1 Dawood T, Schlaich M, Brown A, Lambert G. Depression and blood pressure control: all antidepressants are not the same. Hypertension. 2009; 54: e1.LinkGoogle Scholar2 Licht CMM, de Geus JCN, Zitman FG, Hoogendijk WJG, van Dyck R, Penninx BWJH. Heart rate variability and major depressive disorder in the Netherlands Study on Depression and Anxiety: NESDA. Arch Gen Psychiatry. 2008; 65: 1358–1367.CrossrefMedlineGoogle Scholar3 Licht CMM, de Geus JCN, van Dyck R, Penninx BWJH. The association between anxiety disorders and heart rate variability in the Netherlands Study of Depression and Anxiety: NESDA. Psychosom Med. In press.Google Scholar4 Barton DA, Dawood T, Lambert EA, Esler MD, Haikerwal D, Brenchley C, Socratous F, Kaye DM, Schlaich MP, Hickie I, Lambert GW. Sympathetic activity in major depressive disorder: identifying those at increased cardiac risk? J Hypertens. 2007; 25: 2117–2124.CrossrefMedlineGoogle Scholar5 Cacioppo JT, Uchino BN, Berntson GG. Individual differences in the autonomic origins of heart rate reactivity: the psychometrics of respiratory sinus arrhythmia and preejection period. Psychophysiology. 1994; 31: 412–419.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Stanton A, Handy A and Meston C (2018) The Effects of Exercise on Sexual Function in Women, Sexual Medicine Reviews, 10.1016/j.sxmr.2018.02.004, 6:4, (548-557), Online publication date: 1-Oct-2018. Lorenz T and Meston C (2012) Acute Exercise Improves Physical Sexual Arousal in Women Taking Antidepressants, Annals of Behavioral Medicine, 10.1007/s12160-011-9338-1, 43:3, (352-361), Online publication date: 1-Jun-2012. Licht C, Penninx B and de Geus E (2012) Effects of Antidepressants, but not Psychopathology, on Cardiac Sympathetic Control: A Longitudinal Study, Neuropsychopharmacology, 10.1038/npp.2012.107, 37:11, (2487-2495), Online publication date: 1-Oct-2012. July 2009Vol 54, Issue 1 Advertisement Article InformationMetrics https://doi.org/10.1161/HYPERTENSIONAHA.109.133512 Originally publishedMay 18, 2009 PDF download Advertisement SubjectsClinical StudiesEpidemiologyEtiologyHypertensionTreatment