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Cover Picture: Manufacturing Immunity to Disease in a Test Tube: The Magic Bullet Realized (Angew. Chem. Int. Ed. 48/2006)

2006; Wiley; Volume: 45; Issue: 48 Linguagem: Inglês

10.1002/anie.200690167

1521-3773

Richard A. Lerner,

Historical Medical Research and Treatments

In Paul Ehrlich's era selecting an antibody for a specific target was a physical process, involving live animals. R. A. Lerner shows in his Review on page 8106 ff. how combinatorial libraries are the incarnation of Ehrlich's (see inset in the cover picture showing “Der Bücherwurm” by Carl Spitzweg) “magic bullet”, proposed more than 100 years ago, and nowadays hundreds of millions of different antibodies can be provided in a couple of hundred microliters of solution in a test tube.