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In-beam PET imaging for the control of heavy-ion tumour therapy

1997; Institute of Electrical and Electronics Engineers; Volume: 44; Issue: 4 Linguagem: Inglês

10.1109/23.632694

1558-1578

Jörg Pawelke, W. Enghardt, T. Haberer, B.G. Hasch, Rainer Hinz, Martina Krämer, E. Lauckner, M. Sobiella,

Radiation Effects in Electronics

A method for the in-situ control of the heavy-ion tumour therapy by means of positron emission tomography is introduced. This method is founded on the measurement of the dynamic spatial distributions of /spl beta//sup +/-emitters generated by nuclear fragmentation during the irradiation and their relation to the dose. In order to study this relationship and to derive the dose distribution from the measured /spl beta//sup +/-activity distribution, a framework of model calculations is used. Results of phantom experiments with /sup 12/C ion beams are presented, demonstrating good agreement between experiment and calculation as well as the possibilities and limits of the PET-technique for treatment plan verification and beam monitoring.