Peptide profiling in epithelial tumor plasma by the emerging proteomic techniques
2005; Elsevier BV; Volume: 819; Issue: 1 Linguagem: Inglês
10.1016/j.jchromb.2005.01.022
ISSN1873-376X
AutoresEmilia Caputo, Maria Luisa Lombardi, V. Luongo, Ramy Moharram, Pete Tornatore, Giuseppe Pirozzi, John Guardiola, Brian M. Martin,
Tópico(s)Protease and Inhibitor Mechanisms
ResumoThe plasma peptide component (PPC) from ten melanoma (Mel), breast cancer (BC) and healthy individuals was examined by a combination of RP-HPLC, surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) and tandem mass spectrometry. A three peak pattern (2023, 2039, 2053.5 m/z) was primarily observed in melanoma. Two peaks (2236.1 and of 2356.3 m/z) were found only in BC samples. Fibrinogen alpha and inter-α-trypsin inhibitor heavy chain H4 fragments were absent in both tumor samples.
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