Allergic contact reaction to dexpanthenol: lymphocyte transformation test and evidence for microsomal‐dependent metabolism of the allergen
1993; Wiley; Volume: 28; Issue: 2 Linguagem: Inglês
10.1111/j.1600-0536.1993.tb03346.x
ISSN1600-0536
AutoresC. Hahn, Stefani Rritzsche, Rainier Fritzsche, Rosemarie Schneider, Hans F. Merk,
Tópico(s)Allergic Rhinitis and Sensitization
ResumoIn a patient with contact dermatitis, dexpanthenol was found to be the causative allergen. There was a positive reaction to dexpanthenol on patch testing. Controls did not show any positive reactions to dexpanthenol on patch testing. Additionally, an LTT was performed, Alter pre‐incubation with dexpanthenoi‐modified microsomes. we observed an increase in lymphocyte proliferation to dexpamhenol, in comparison to dexpamhenol without microsomes. suggesting that microsomes metabolism plays a role in the pathogenesis of dexpanthenol sensitization, because microsomes are known to posses drug metabolizing enzymes such as cytochrome P450.
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