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Sequence Variants in Kynurenine Aminotransferase II (KAT II) Orthologs Determine Different Potencies of the Inhibitor S ‐ESBA

2008; Wiley; Volume: 3; Issue: 8 Linguagem: Inglês

10.1002/cmdc.200800109

1860-7187

Roberto Pellicciari, Francesco Venturoni, Daniele Bellocchi, Andrea Carotti, Maura Marinozzi, Antonio Macchiarulo, Laura Amori, Robert Schwarcz,

Bipolar Disorder and Treatment

We report a novel and more efficient synthesis of S-ESBA and an analysis of it inhibitory activity toward recombinant human KAT II. The data are discussed in light of the crystal structure of human KAT II and on the basis of conserved and nonconserved residues of species-specific orthologs of KAT II (human, rat, and mouse).