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Post-operative endothelial dysfunction assessment using laser Doppler perfusion measurement in cardiac surgery patients
2014; Wiley; Volume: 58; Issue: 4 Linguagem: Inglês
10.1111/aas.12286
ISSN1399-6576
AutoresAG Vizzoni, Marília Brito Gomes, Eduardo Tibiriçá, Marcos Adriano Lessa,
Tópico(s)Infrared Thermography in Medicine
ResumoActa Anaesthesiologica ScandinavicaVolume 58, Issue 4 p. 468-477 Intensive Care and Physiology Post-operative endothelial dysfunction assessment using laser Doppler perfusion measurement in cardiac surgery patients V. GOMES, V. GOMES Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, BrazilSearch for more papers by this authorM. B. GOMES, M. B. GOMES Department of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Rio de Janeiro, BrazilSearch for more papers by this authorE. TIBIRICA, E. TIBIRICA Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, BrazilSearch for more papers by this authorM. A. LESSA, Corresponding Author M. A. LESSA Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Brazil Address: Marcos Adriano Lessa Laboratory of Cardiovascular Investigation Oswaldo Cruz Institute/FIOCRUZ 4365 Brasil Avenue 21045 900 Rio de Janeiro Brazil e-mail: [email protected]Search for more papers by this author V. GOMES, V. GOMES Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, BrazilSearch for more papers by this authorM. B. GOMES, M. B. GOMES Department of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro, Rio de Janeiro, BrazilSearch for more papers by this authorE. TIBIRICA, E. TIBIRICA Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, BrazilSearch for more papers by this authorM. A. LESSA, Corresponding Author M. A. LESSA Laboratory of Cardiovascular Investigation, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Brazil Address: Marcos Adriano Lessa Laboratory of Cardiovascular Investigation Oswaldo Cruz Institute/FIOCRUZ 4365 Brasil Avenue 21045 900 Rio de Janeiro Brazil e-mail: [email protected]Search for more papers by this author First published: 12 March 2014 https://doi.org/10.1111/aas.12286Citations: 12Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Background Coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) is associated with systemic inflammatory response and endothelial dysfunction. Our hypothesis is that CPB-induced post-operative endothelial dysfunction may be detected using laser Doppler perfusion monitoring (LDPM) in the skin microcirculation. Methods We used LDPM to investigate the subacute effects of the CPB on systemic microvascular reactivity among patients undergoing CABG surgery with CPB. Thirty patients were submitted to the study of skin microcirculation and blood sample collection at baseline (pre-surgery) and at 7 days post-surgical procedure. The skin microcirculation was evaluated by acetylcholine (ACh) and sodium nitroprusside (SNP) iontophoresis, and thermal hyperemia (TH). Plasma levels of nitrite/nitrate were also analyzed, and cytokine profiles were determined using a multiplex system. Results On-pump CABG surgery induced a significant reduction of the increased microvascular dermal flux observed after cumulative doses of ACh iontophoresis and after TH. On-pump CABG surgery did not induce any significant changes in the microvascular flux after cumulative doses of SNP. Patients still presented high levels of interleukin (IL)-6, IL-8, and C-reactive protein, and low bioavailability of nitric oxide 7 days after the CABG surgery with CPB. Conclusion We observed a significant impairment of systemic microvascular endothelial function and well-preserved endothelium-independent vasodilatation in the skin microcirculation of patients 1 week after CABG surgery with CPB. Our results suggest that LDPM is a useful tool for the assessment of on-pump CABG-induced subacute post-operative endothelial dysfunctions. Citing Literature Volume58, Issue4April 2014Pages 468-477 RelatedInformation
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