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TRIENINE, AN ANTITUMOR TRIENE ANTIBIOTIC

1968; Springer Nature; Volume: 21; Issue: 10 Linguagem: Inglês

10.7164/antibiotics.21.611

1881-1469

Adorján Aszalós, Robert S. Robison, PAUL LEMANSKI, Bernard Berk,

Click Chemistry and Applications

Trienine, a new antitumor antibiotic, was isolated from the fermentation broth of Streptomyces SC3725. The substance, which contains three conjugated double bonds in a molecule weighing approximately 1, 400, is active in vitro against gram-positive bacteria, as well as against several yeast and fungi. Trienine is also active as an inhibitor of the growth of the 5 WM tumor.