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Immune Response, Diagnosis and Treatment of Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis Lung Disease

2013; Bentham Science Publishers; Volume: 19; Issue: 20 Linguagem: Inglês

10.2174/13816128113199990349

1873-4286

Olaf Eickmeier, Nikolaus Rieber, Jonas Eckrich, Andreas Hector, Ute Graeppler-Mainka, Dominik Hartl,

Infectious Diseases and Mycology

Patients with cystic fibrosis (CF) suffer from chronic infective lung disease, which determines morbidity and mortality. While bacteria, such as Pseudomonas aeruginosa, are well-known to contribute to pulmonary pathology, the relevance of fungi in CF airways remains poorly understood. The best studied fungus in CF is Aspergillus fumigatus, which frequently colonizes CF airways and causes a disease condition termed allergic bronchopulmonary aspergillosis. This review aims to provide an update on the immunological mechanisms, diagnostic approaches and therapeutic strategies for allergic bronchopulmonary aspergillosis and other Aspergillus fumigatusmediated phenotypes in CF lung disease. Keywords: Cystic fibrosis, Allergic Bronchopulmonary Aspergillosis (ABPA), Immune response.