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Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG

1998; Cambridge University Press; Volume: 116; Issue: 3 Linguagem: Inglês

10.1017/s0031182097002175

1469-8161

Anuradha Dube, Preeti Sharma, Janmejai Kumar Srivastava, A. Misra, S. R. Naik, J. C. Katiyar,

Trypanosoma species research and implications

The protective potential of killed Leishmania major (ALM) along with BCG was evaluated against L. donovani in Indian langur monkeys in single and triple dose schedules. A delayed protection was observed in monkeys after a single dose schedule of ALM (3 mg)+BCG (3 mg) given intradermally 2 months before intravenous challenge with L. donovani. Triple dose schedule each of 1 mg ALM + 1 mg BCG was more effective. The status remained unchanged until the end of the experiment (approximately 8 months). The study indicates that a combination of ALM + BCG may be a good candidate vaccine for exploiting against human Kala-azar.