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New Insights into mTOR Signaling: mTORC2 and Beyond

2009; American Association for the Advancement of Science; Volume: 2; Issue: 67 Linguagem: Inglês

10.1126/scisignal.267pe27

1937-9145

Dario R. Alessi, Laura R. Pearce, Juan Manuel García‐Martínez,

Coagulation, Bradykinin, Polyphosphates, and Angioedema

The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in regulating cell growth and proliferation. mTORC2 promotes the activation of the serum glucocorticoid-induced protein kinase (SGK). This mTOR complex also promotes the constitutive phosphorylation of proline-directed serine or threonine sites in the turn motif of Akt and protein kinase C isoforms. mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase.