Novel Cinchona ‐Aminobenzimidazole Bifunctional Organocatalysts
2009; Wiley; Volume: 351; Issue: 18 Linguagem: Inglês
10.1002/adsc.200900787
ISSN1615-4169
AutoresLei Zhang, Myoung‐Mo Lee, Soomi Lee, Jihye Lee, Maosheng Cheng, Byeong‐Seon Jeong, Hyeung‐geun Park, Sang‐sup Jew,
Tópico(s)Chemical Synthesis and Reactions
ResumoAbstract Efficient Cinchona ‐derived chiral 2‐aminobenzimidazole catalysts were prepared by the coupling of 5,7‐bis(trifluoromethyl)‐2‐chlorobenzimidazole with C(9 S )‐aminodihydroquinine or C(9 R )‐aminodihydroquinidine and successively applied to the Michael addition of dimethyl malonate to nitroolefins as very efficient chiral Lewis acid bifunctional organocatalysts (up to >99% ee ).
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