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Bovine Lactoferrin Inhibits Adenovirus Infection by Interacting with Viral Structural Polypeptides

2003; American Society for Microbiology; Volume: 47; Issue: 8 Linguagem: Inglês

10.1128/aac.47.8.2688-2691.2003

1098-6596

Agostina Pietrantoni, Assunta Maria Di Biase, Antonella Tinari, М. Marchetti, Piera Valenti, L Seganti, Fabiana Superti,

Respiratory viral infections research

ABSTRACT We recently demonstrated that lactoferrin, an antimicrobial glycoprotein, can inhibit adenovirus infection by competing for common glycosaminoglycan receptors. This study further characterizes the antiadenovirus activity of the protein, thus demonstrating that lactoferrin neutralizes infection by binding to adenovirus particles and that its targets are viral III and IIIa structural polypeptides.