Produção Nacional
Revisado por pares
The cerebellum in Parkinson’s disease and parkinsonism in cerebellar disorders
2013; Oxford University Press; Volume: 136; Issue: 9 Linguagem: Inglês
10.1093/brain/awt089
ISSN1460-2156
AutoresJosé Luiz Pedroso, Pedro Braga‐Neto, Paulo Victor Sgobbi de Souza, Orlando Graziani Póvoas Barsottini,
Tópico(s)Parkinson's Disease Mechanisms and Treatments
ResumoSir, We have read with great interest the article by Wu and Hallett (2013) entitled ‘The cerebellum in Parkinson’s disease’. These authors reviewed related anatomical, clinical and neurophysiological findings, and discuss the possible roles of the cerebellum in the pathophysiology of Parkinson’s disease. They pointed out that Parkinson’s disease is associated with pathological and structural changes in the cerebellum, and also stated that functional neuroimaging has demonstrated increased activation of the cerebellum in Parkinson’s disease. Furthermore, tremor and cerebellar involvement is discussed in Parkinson’s disease, and a primary dysfunction in the cerebello-thalamo-cortical circuit, particularly the vermis/paravermis region, is thought to be responsible for the occurrence of resting tremor. Another assumption is that functional or structural changes in the cerebellum may contribute to non-motor symptoms …
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