Characterization of a Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Strain in a Patient with Endocarditis
2007; American Society for Microbiology; Volume: 51; Issue: 9 Linguagem: Inglês
10.1128/aac.00559-07
ISSN1098-6596
AutoresKathleen G. Julian, Klaudia Kosowska-Shick, Cynthia Whitener, Martin Roos, Harald Labischinski, Aileen Rubio, Leslie J. Parent, Lois M. Ednie, Laura Koeth, Tatiana Bogdanovich, Peter C. Appelbaum,
Tópico(s)Bacterial Identification and Susceptibility Testing
ResumoABSTRACT We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O -acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.
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