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BIBTEX RIS

Sequencing and Comparative Genomic Analysis of pK29, a 269-Kilobase Conjugative Plasmid Encoding CMY-8 and CTX-M-3 β-Lactamases in Klebsiella pneumoniae

2007; American Society for Microbiology; Volume: 51; Issue: 8 Linguagem: Inglês

10.1128/aac.00167-07

ISSN

1098-6596

Autores

Ying-Tsong Chen, Tsai‐Ling Lauderdale, Tsai-Lien Liao, Yih‐Ru Shiau, Hung‐Yu Shu, Keh-Ming Wu, Jing-Jou Yan, Ih‐Jen Su, Shih‐Feng Tsai,

Tópico(s)

Bacterial Genetics and Biotechnology

Resumo

ABSTRACT A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum β-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.

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