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Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response

2014; American Association for the Advancement of Science; Volume: 343; Issue: 6176 Linguagem: Inglês

10.1126/science.1249845

1095-9203

Yuchen Han, Jesse Donovan, Sneha Rath, Gena Whitney, Alisha Chitrakar, Alexei Korennykh,

RNA regulation and disease

Crossed Homodimer Our cells respond to infection by releasing interferons, which protect neighboring cells, in part through the cleavage of intracellular RNA by a protein kinase family receptor, RNase L. RNase L is activated by 2′,5″-linked oligoadenylates (the second messenger 2-5 A), sensors of pathogen- and damage-associated RNA. Han et al. (p. 1244 , published online 27 February) report crystal structures of human RNase L in complexes with 2-5 A, nucleotides, and an 18-nucleotide oligomer RNA target.