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Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration

2011; Oxford University Press; Volume: 20; Issue: 18 Linguagem: Inglês

10.1093/hmg/ddr270

1460-2083

Yi Yu, Tushar Bhangale, Jesen Fagerness, Stephan Ripke, Guðmar Þorleifsson, Perciliz L. Tan, Eric H. Souied, Andrea J. Richardson, Joanna E. Merriam, Gabriëlle H.S. Buitendijk, Robyn Reynolds, Soumya Raychaudhuri, Kimberly Chin, Lucia Sobrin, Εvangelos Εvangelou, Phil H. Lee, Aaron Lee, Nicolas Leveziel, Donald J. Zack, Betsy Campochiaro, Peter A. Campochiaro, R. Theodore Smith, Gaetano R. Barile, Robyn H. Guymer, Ruth Hogg, Usha Chakravarthy, Luba Robman, Ómar Gústafsson, Haraldur Sigurðsson, Ward Ortmann, Timothy W. Behrens, Kári Stéfansson, André G. Uitterlinden, Cornelia M. van Duijn, Johannes R. Vingerling, Caroline C. W. Klaver, Rando Allikmets, Milam A. Brantley, Paul N. Baird, Nicholas Katsanis, Unnur Þorsteinsdóttir, John P. A. Ioannidis, Mark J. Daly, Robert Graham, Johanna M. Seddon,

Retinal Development and Disorders

Despite significant progress in the identification of genetic loci for age-related macular degeneration (AMD), not all of the heritability has been explained. To identify variants which contribute to the remaining genetic susceptibility, we performed the largest meta-analysis of genome-wide association studies to date for advanced AMD. We imputed 6 036 699 single-nucleotide polymorphisms with the 1000 Genomes Project reference genotypes on 2594 cases and 4134 controls with follow-up replication of top signals in 5640 cases and 52 174 controls. We identified two new common susceptibility alleles, rs1999930 on 6q21-q22.3 near FRK/COL10A1 [odds ratio (OR) 0.87; P = 1.1 × 10−8] and rs4711751 on 6p12 near VEGFA (OR 1.15; P = 8.7 × 10−9). In addition to the two novel loci, 10 previously reported loci in ARMS2/HTRA1 (rs10490924), CFH (rs1061170, and rs1410996), CFB (rs641153), C3 (rs2230199), C2 (rs9332739), CFI (rs10033900), LIPC (rs10468017), TIMP3 (rs9621532) and CETP (rs3764261) were confirmed with genome-wide significant signals in this large study. Loci in the recently reported genes ABCA1 and COL8A1 were also detected with suggestive evidence of association with advanced AMD. The novel variants identified in this study suggest that angiogenesis (VEGFA) and extracellular collagen matrix (FRK/COL10A1) pathways contribute to the development of advanced AMD.