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Ebolavirus comparative genomics

2015; Oxford University Press; Volume: 39; Issue: 5 Linguagem: Inglês

10.1093/femsre/fuv031

1574-6976

Se‐Ran Jun, Michael R. Leuze, Intawat Nookaew, Edward C. Uberbacher, Miriam Land, Qian Zhang, Visanu Wanchai, Juanjuan Chai, Morten Nielsen, Thomas Trolle, Ole Lund, Gregory S. Buzard, Thomas Lin Pedersen, Trudy M. Wassenaar, David W. Ussery,

Viral gastroenteritis research and epidemiology

The 2014 Ebola outbreak in West Africa is the largest documented for this virus. To examine the dynamics of this genome, we compare more than 100 currently available ebolavirus genomes to each other and to other viral genomes. Based on oligomer frequency analysis, the family Filoviridae forms a distinct group from all other sequenced viral genomes. All filovirus genomes sequenced to date encode proteins with similar functions and gene order, although there is considerable divergence in sequences between the three genera Ebolavirus, Cuevavirus and Marburgvirus within the family Filoviridae. Whereas all ebolavirus genomes are quite similar (multiple sequences of the same strain are often identical), variation is most common in the intergenic regions and within specific areas of the genes encoding the glycoprotein (GP), nucleoprotein (NP) and polymerase (L). We predict regions that could contain epitope-binding sites, which might be good vaccine targets. This information, combined with glycosylation sites and experimentally determined epitopes, can identify the most promising regions for the development of therapeutic strategies.