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Prevalence and predictors of refractive error in a genetically isolated population: the Norfolk Island Eye Study

2011; Wiley; Volume: 39; Issue: 8 Linguagem: Inglês

10.1111/j.1442-9071.2011.02579.x

1442-9071

Justin C. Sherwin, John L. Kelly, Alex W. Hewitt, Lisa S. Kearns, Lyn R. Griffiths, David A. Mackey,

Glaucoma and retinal disorders

Clinical & Experimental OphthalmologyVolume 39, Issue 8 p. 734-742 Prevalence and predictors of refractive error in a genetically isolated population: the Norfolk Island Eye Study Justin C Sherwin MBBS(Hons), Justin C Sherwin MBBS(Hons) Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UKSearch for more papers by this authorJohn Kelly BAppSc, John Kelly BAppSc Norfolk Optical, Norfolk, UKSearch for more papers by this authorAlex W Hewitt PhD, Alex W Hewitt PhD Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, VictoriaSearch for more papers by this authorLisa S Kearns BOrth&OphthalSci(Hons), Lisa S Kearns BOrth&OphthalSci(Hons) Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, VictoriaSearch for more papers by this authorLyn R Griffiths PhD, Lyn R Griffiths PhD Genomic Research Centre, Griffith Health Institute, Griffith University, Southport, QueenslandSearch for more papers by this authorDavid A Mackey MD FRANZCO, Corresponding Author David A Mackey MD FRANZCO Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria Department of Ophthalmology, Royal Hobart Hospital, University of Tasmania, Hobart, Tasmania Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Western Australia, AustraliaProfessor David A Mackey, Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, 2 Verdun St, Nedlands, WA 6009, Australia. Email: [email protected]Search for more papers by this author Justin C Sherwin MBBS(Hons), Justin C Sherwin MBBS(Hons) Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UKSearch for more papers by this authorJohn Kelly BAppSc, John Kelly BAppSc Norfolk Optical, Norfolk, UKSearch for more papers by this authorAlex W Hewitt PhD, Alex W Hewitt PhD Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, VictoriaSearch for more papers by this authorLisa S Kearns BOrth&OphthalSci(Hons), Lisa S Kearns BOrth&OphthalSci(Hons) Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, VictoriaSearch for more papers by this authorLyn R Griffiths PhD, Lyn R Griffiths PhD Genomic Research Centre, Griffith Health Institute, Griffith University, Southport, QueenslandSearch for more papers by this authorDavid A Mackey MD FRANZCO, Corresponding Author David A Mackey MD FRANZCO Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria Department of Ophthalmology, Royal Hobart Hospital, University of Tasmania, Hobart, Tasmania Centre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Western Australia, AustraliaProfessor David A Mackey, Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, 2 Verdun St, Nedlands, WA 6009, Australia. Email: [email protected]Search for more papers by this author First published: 18 April 2011 https://doi.org/10.1111/j.1442-9071.2011.02579.xCitations: 9Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Background: We aimed to determine the prevalence and associations of refractive error on Norfolk Island. Design: Population-based study on Norfolk Island, South Pacific. Participants: All permanent residents on Norfolk Island aged ≥15 years were invited to participate. Methods: Patients underwent non-cycloplegic autorefraction, slit-lamp biomicroscope examination and biometry assessment. Only phakic eyes were analysed. Main Outcome Measures: Prevalence and multivariate associations of refractive error and myopia. Results: There were 677 people (645 right phakic eyes, 648 left phakic eyes) aged ≥ 15 years were included in this study. Mean age of participants was 51.1 (standard deviation 15.7; range 15–81). Three hundred and seventy-six people (55.5%) were female. Adjusted to the 2006 Norfolk Island population, prevalence estimates of refractive error were as follows: myopia (mean spherical equivalent ≥−1.0 D) 10.1%, hypermetropia (mean spherical equivalent ≥ 1.0 D) 36.6%, and astigmatism 17.7%. Significant independent predictors of myopia in the multivariate model were lower age (P < 0.001), longer axial length (P < 0.001), shallower anterior chamber depth (P = 0.031) and increased corneal curvature (P < 0.001). Significant independent predictors of refractive error were increasing age (P < 0.001), male gender (P = 0.009), Pitcairn ancestry (P = 0.041), cataract (P < 0.001), longer axial length (P < 0.001) and decreased corneal curvature (P < 0.001). Conclusions: The prevalence of myopia on Norfolk Island is lower than on mainland Australia, and the Norfolk Island population demonstrates ethnic differences in the prevalence estimates. Given the significant associations between refractive error and several ocular biometry characteristics, Norfolk Island may be a useful population in which to find the genetic basis of refractive error. Citing Literature Volume39, Issue8November 2011Pages 734-742 RelatedInformation