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One or two day mifepristone–misoprostol interval for second trimester abortion

2007; Informa; Volume: 86; Issue: 9 Linguagem: Inglês

10.1080/00016340701505002

1600-0412

Lisbeth Nilas, Marianne Glavind‐Kristensen, Thomas S Vejborg, Ulla Breth Knudsen,

Maternal and Perinatal Health Interventions

A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h.The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98% within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001).The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care.