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Artigo Revisado por pares
BIBTEX RIS

Importance of Ring Puckering versus Interstrand Hydrogen Bonds for the Conformational Stability of Collagen

2011; Wiley; Volume: 50; Issue: 30 Linguagem: Inglês

10.1002/anie.201008118

ISSN

1521-3773

Autores

Roman S. Erdmann, Helma Wennemers,

Tópico(s)

Proteoglycans and glycosaminoglycans research

Resumo

Mismatch is fine: Proline derivatives with a ring pucker mismatching that of natural collagen but with favorable torsional angles along the peptide chain are readily tolerated within the collagen triple helix (see picture). In contrast, a competition between intramolecular and interstrand H bonds destabilizes the collagen triple helix.

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