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Central Nervous System Herpes Simplex and Varicella Zoster Virus Infections in Natalizumab-Treated Patients

2013; Oxford University Press; Volume: 57; Issue: 6 Linguagem: Inglês

10.1093/cid/cit376

1537-6591

Andrew J. Fine, Alfred Sorbello, Cindy Kortepeter, Linda Scarazzini,

Herpesvirus Infections and Treatments

We report on 20 natalizumab-treated patients with multiple sclerosis who developed laboratory-confirmed central nervous system (CNS) herpesvirus infections. In addition to progressive multifocal leukoencephalopathy, other CNS opportunistic infections have been rarely reported during natalizumab treatment. We encourage heightened awareness due to the risk for serious outcomes.