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miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1

2014; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 7 Linguagem: Inglês

10.3390/ijms150711973

1661-6596

Hui Xia, Shengjie Sun, Bo Wang, Tao Wang, Chaoyang Liang, Li Guo, Chongbiao Huang, Daliang Qi, Xiangyang Chu,

RNA modifications and cancer

MicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the roles and mechanisms of miR-143 in non-small cell lung cancer (NSCLC). miR-143 was significantly decreased in NSCLC tissues and cell lines. Overexpression of miR-143 suppressed NSCLC cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct and functional target of miR-143. Overexpression of Limk1 attenuated the tumor suppressive effects of miR-143 in NSCLC cells. Moreover, miR-143 was inversely correlated with Limk1 expression in NSCLC tissues. Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC.