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The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review

2009; Oxford University Press; Volume: 49; Issue: 2 Linguagem: Inglês

10.1093/rheumatology/kep366

1462-0332

Sarah Westlake, Alexandra N. Colebatch, Janis Baird, Patrick Kiely, Mark Quinn, Ernest Choy, A. J. Ostor, C J Edwards,

Chronic Lymphocytic Leukemia Research

Objectives. Patients with RA have an increased prevalence of cardiovascular disease (CVD). This is due to traditional risk factors and the effects of chronic inflammation. MTX is the first-choice DMARD in RA. We performed a systematic literature review to determine whether MTX affects the risk of CVD in patients with RA.