Portal de Periódicos da CAPES

α-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii

1975; Elsevier BV; Volume: 32; Issue: 2 Linguagem: Inglês

10.1016/0014-2999(75)90305-2

1879-0712

Frans P. Nijkamp, Wybren de Jong,

Traumatic Brain Injury and Neurovascular Disturbances

Bilateral injections of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the brain stem caused a dose-dependent decrease of systemic arterial blood pressure and heart rate of anesthetized rats. The effects were prevented and even reversed by a preceding injection of the alpha-adrenoceptor blocking agent phentolamine. Pressor doses of angiotensin II and of arginine-vasopressin at the same site failed to drcrease blood pressure and heart rate.