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COMPARISON OF THE UROPROTECTIVE EFFICACY OF MESNA AND HBO TREATMENTS IN CYCLOPHOSPHAMIDE-INDUCED HEMORRHAGIC CYSTITIS

1997; Lippincott Williams & Wilkins; Volume: 158; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(01)68238-7

1527-3792

Özdal Etlik, Ahmet Tomur, Salih Deveci, İlksin Pişkin, Mesut Pekcan,

Hematopoietic Stem Cell Transplantation

No AccessJournal of UrologyInvestigative Urology1 Dec 1997COMPARISON OF THE UROPROTECTIVE EFFICACY OF MESNA AND HBO TREATMENTS IN CYCLOPHOSPHAMIDE-INDUCED HEMORRHAGIC CYSTITIS Ozdal Etlik, Ahmet Tomur, Salih Deveci, Ilksin Piskin, and Mesut Pekcan Ozdal EtlikOzdal Etlik , Ahmet TomurAhmet Tomur , Salih DeveciSalih Deveci , Ilksin PiskinIlksin Piskin , and Mesut PekcanMesut Pekcan View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)68238-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The aim of this research was to compare the protective effects of mesna, hyperbaric oxygenation (HBO), and their combination in cyclophosphamide-induced hemorrhagic cystitis in guinea pigs. Following one dose of i.p. 21.5 mg./kg. mesna administration 20 minutes before i.p. 68.1 mg./kg. cyclophosphamide, 3 additional doses of mesna were given every three hours. A total of 8 HBO exposures, 5 of which were applied prophylactically before cyclophosphamide, were performed at 2.8 ATA for 90 minutes 2 times a day. Although mesna or HBO provided significant protection for cyclophosphamide-cystitis in animal bladders, there was also significant damage compared with controls. The combination of mesna and HBO, which act through independent mechanisms, resulted in complete protection, since mean histological scores and hematuria levels in this group were not different from controls (p >0.05). Therefore, this combination may be a useful tool in the prophylaxis and treatment of cyclophosphamide-induced hemorrhagic cystitis. References 1 : Urologic complications of cyclophosphamide.. Br. J. Urol.1973; 45: 609. Google Scholar 2 : Cyclophosphamide and urinary bladder toxicity.. Cancer Res.1961; 21: 1557. Google Scholar 3 : Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention.. 1. 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Google Scholar From the Departments of Physiology and Pathology, Gulhane Military Medical Academy, Ankara, Turkey.Accepted for publication June 6, 1997.Requests for reprints: Department of Physiology, GATA 06018, Etlik/Ankara, Turkey.This research was supported by funds of the scientific board of Gulhane Military Medical Academy Research Center.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byKiuchi H, Takao T, Yamamoto K, Nakayama J, Miyagawa Y, Tsujimura A, Nonomura N and Okuyama A (2018) Sesquiterpene Lactone Parthenolide Ameliorates Bladder Inflammation and Bladder Overactivity in Cyclophosphamide Induced Rat Cystitis Model by Inhibiting Nuclear Factor-κB PhosphorylationJournal of Urology, VOL. 181, NO. 5, (2339-2348), Online publication date: 1-May-2009.BRATSAS K, STEPHANIDES A, SPYROPOULOS E, ZACHARIADES B and ANDROULAKAKIS P (2018) HYPERBARIC OXYGEN THERAPY FOR CYCLOPHOSPHAMIDE INDUCED REFRACTORY HEMORRHAGIC CYSTITIS IN A CHILDJournal of Urology, VOL. 172, NO. 2, (679-679), Online publication date: 1-Aug-2004.KORKMAZ A, OTER S, DEVECİ S, GOKSOY C and BİLGİC H (2018) PREVENTION OF FURTHER CYCLOPHOSPHAMIDE INDUCED HEMORRHAGIC CYSTITIS BY HYPERBARIC OXYGEN AND MESNA IN GUINEA PIGSJournal of Urology, VOL. 166, NO. 3, (1119-1123), Online publication date: 1-Sep-2001.FURNESS P, PALMER L, PALMER J, CAPELLI-SCHELLPFEFFER M and CHENG E (2018) HYPERBARIC OXYGEN THERAPY FOR PEDIATRIC HEMORRHAGIC CYSTITISJournal of Urology, VOL. 161, NO. 5, (1596-1597), Online publication date: 1-May-1999.Ratliff T and Williams R (2018) EDITORIAL: HEMORRHAGIC CYSTITIS, CHEMOTHERAPY, AND BLADDER TOXICITYJournal of Urology, VOL. 159, NO. 3, (1044-1044), Online publication date: 1-Mar-1998. Volume 158Issue 6December 1997Page: 2296-2299 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Ozdal Etlik More articles by this author Ahmet Tomur More articles by this author Salih Deveci More articles by this author Ilksin Piskin More articles by this author Mesut Pekcan More articles by this author Expand All Advertisement PDF downloadLoading ...