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Hepatitis delta virus genotype IIb predominates in an endemic area, Okinawa, Japan

1999; Wiley; Volume: 58; Issue: 4 Linguagem: Inglês

10.1002/(sici)1096-9071(199908)58

1096-9071

Hiroshi Sakugawa, Hiroki Nakasone, Tomofumi Nakayoshi, Yuko Kawakami, Shiro Miyazato, Fukunori Kinjo, Atsushi Saitô, Shao‐Ping Ma, Hak Hotta, Moritoshi Kinoshita,

Hepatitis Viruses Studies and Epidemiology

Journal of Medical VirologyVolume 58, Issue 4 p. 366-372 Hepatitis delta virus genotype IIb predominates in an endemic area, Okinawa, Japan† Hiroshi Sakugawa, Corresponding Author Hiroshi Sakugawa [email protected] First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanFirst Department of Internal Medicine, University Hospital, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Okinawa, Japan===Search for more papers by this authorHiroki Nakasone, Hiroki Nakasone First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorTomofumi Nakayoshi, Tomofumi Nakayoshi First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorYuko Kawakami, Yuko Kawakami First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorShiro Miyazato, Shiro Miyazato First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorFukunori Kinjo, Fukunori Kinjo First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorAtsushi Saito, Atsushi Saito First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorShao-Ping Ma, Shao-Ping Ma Department of Virology, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorHak Hotta, Hak Hotta Department of Microbiology, Kobe University School of Medicine, Hyogo, JapanSearch for more papers by this authorMoritoshi Kinoshita, Moritoshi Kinoshita Otsuka Assay Laboratories, Otsuka Pharmaceutical Company, Limited, Tokushima, JapanSearch for more papers by this author Hiroshi Sakugawa, Corresponding Author Hiroshi Sakugawa [email protected] First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanFirst Department of Internal Medicine, University Hospital, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Okinawa, Japan===Search for more papers by this authorHiroki Nakasone, Hiroki Nakasone First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorTomofumi Nakayoshi, Tomofumi Nakayoshi First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorYuko Kawakami, Yuko Kawakami First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorShiro Miyazato, Shiro Miyazato First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorFukunori Kinjo, Fukunori Kinjo First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorAtsushi Saito, Atsushi Saito First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorShao-Ping Ma, Shao-Ping Ma Department of Virology, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, JapanSearch for more papers by this authorHak Hotta, Hak Hotta Department of Microbiology, Kobe University School of Medicine, Hyogo, JapanSearch for more papers by this authorMoritoshi Kinoshita, Moritoshi Kinoshita Otsuka Assay Laboratories, Otsuka Pharmaceutical Company, Limited, Tokushima, JapanSearch for more papers by this author First published: 06 July 1999 https://doi.org/10.1002/(SICI)1096-9071(199908)58:4 3.0.CO;2-XCitations: 54 † The nucleotide sequence data reported in this article will appear in the DDBJ/EMBL/GenBank nucleotide sequence databases with accession numbers ABO 15442–ABO 15447 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Hepatitis delta virus (HDV) infection is relatively common in the Miyako Islands, Okinawa, Japan, where the infection has been reported to be associated with low pathogenicity. HDV RNA extracted from each of 6 patients with HDV-related chronic liver disease living in the islands was amplified by reverse transcription-polymerase chain reaction and examined genetically to determine the HDV genotype. All isolates from the 6 patients were classified as genotype II by the neighbor-joining method. However, these isolates had relatively low homology (75–81%) to the HDV genotype II isolate reported from Japan, and showed relatively high identity (83–95%) to the novel genotype II isolate (HDV genotype IIb) recently reported from Taiwan. Phylogenetic analysis showed that the 6 isolates form a novel group within HDV genotype II. 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