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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Interstitial expression of heat shock protein 47 and α-smooth muscle actin in renal allograft failure

2000; Oxford University Press; Volume: 15; Issue: 4 Linguagem: Inglês

10.1093/ndt/15.4.529

ISSN

1460-2385

Autores

Katsushige Abe, Yoshiyuki Ozono, Masanobu Miyazaki, Takehiko Koji, Kei Shioshita, Akira Furusu, Shoko Tsukasaki, Fukuzo Matsuya, Nobuko Hosokawa, Takashi Harada, Takashi Taguchi, Kazuhiro Nagata, Shigeru Kohno,

Tópico(s)

Organ Transplantation Techniques and Outcomes

Resumo

Background. Tubulointerstitial inflammation and fibrosis are the main pathological features of chronic renal allograft rejection, which is characterized by accumulation of extracellular matrix protein. Heat shock protein 47 (HSP47), known as a collagen-specific stress protein, is thought to be a molecular chaperone during the processing and/or secretion of procollagen. HSP47 is thought to be involved in the progression of fibrosis, but its expression in chronic renal allograft rejection is still unknown.

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