Interaction of Monobenzamidine-Linked Trypanocides with the Trypanosoma brucei P2 Aminopurine Transporter
2005; American Society for Microbiology; Volume: 49; Issue: 12 Linguagem: Inglês
10.1128/aac.49.12.5169-5171.2005
ISSN1098-6596
AutoresMhairi Stewart, Cyrille Boussard, Reto Brun, Ian H. Gilbert, Michael P. Barrett,
Tópico(s)Research on Leishmaniasis Studies
ResumoSingle benzamidine group-carrying compounds were shown to interact with the Trypanosoma brucei P2 aminopurine transporter. Replacement of the amidine with a guanidine group decreased affinity. Trypanocidal activity was evident, but compounds were equally toxic against trypanosomes lacking the P2 transporter, which indicates additional uptake routes for monobenzamidine-derived compounds.
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