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Cytokine pattern in very early rheumatoid arthritis favours B cell activation and survival

2010; BioMed Central; Volume: 8; Issue: S1 Linguagem: Inglês

10.1186/1479-5876-8-s1-p33

1479-5876

R. A. Moura, Rita Cascão, Inês P. Perpétuo, Helena Canhão, Elsa Vieira‐Sousa, AF Mourão, Ana Maria Rodrigues, Joaquim Polido‐Pereira, M Viana Queiróz, H.S. Rosário, Margarida Souto‐Carneiro, Luís Graça, João Eurico Fonseca,

T-cell and B-cell Immunology

B cells play an important role in the perpetuation of rheumatoid arthritis (RA), particularly as autoantibody producing cells. The immune complexes that further develop deposit in the joints and aggravate the inflammatory process. However, B cells contribution in the very early stage of the disease remains unknown.