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Immobilized microorganisms in the reduction of ethyl 4-chloro acetoacetate

2009; Elsevier BV; Volume: 20; Issue: 19 Linguagem: Inglês

10.1016/j.tetasy.2009.09.018

1362-511X

Joyce Benzaquem Ribeiro, Aline de Souza Ramos, Sorele Batista Fiaux, Selma Gomes Ferreira Leite, Maria da Conceição Klaus V. Ramos, Francisco Radler de Aquino Neto, Octávio Augusto Ceva Antunes,

Microbial Metabolites in Food Biotechnology

Microorganisms were used to reduce ethyl 4-chloroacetoacetate (CAAE) to ethyl (S)-4-chloro-3-hydroxybutanoate [(S)-CHBE]. Mucor ramannianus provided 98% conversion with 84% ee. Free cells of Kluyveromyces marxianus led to 95% conversion with 81% ee. After a fractionary factorial design to study the reaction conditions, calcium alginate immobilized cells of K. marxianus furnished the product with 99% conversion with 91% ee.