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Predictors of early inactive disease in a juvenile idiopathic arthritis cohort: Results of a Canadian multicenter, prospective inception cohort study

2009; Wiley; Volume: 61; Issue: 8 Linguagem: Inglês

10.1002/art.24539

2151-4658

Kiem Oen, Lori B. Tucker, Adam M. Huber, Päivi Miettunen, Rosie Scuccimarri, Sarah Campillo, David A. Cabral, Brian M. Feldman, Shirley M. L. Tse, Gaëlle Chédeville, Lynn Spiegel, Rayfel Schneider, Bianca Lang, Janet Ellsworth, Suzanne Ramsey, Paul Dancey, Earl D. Silverman, Anne-Laure Chetaille, Bonnie Cameron, Nicole Johnson, Jean Dorval, Ross E. Petty, Karen Watanabe Duffy, Gilles Boire, Élie Haddad, Kristin Houghton, Claire Saint‐Cyr, Stuart E. Turvey, Susanne M. Benseler, Mary Cheang, Rae S. M. Yeung, Ciarán M. Duffy,

Acute Lymphoblastic Leukemia research

Abstract Objective To determine early predictors of 6‐month outcomes in a prospective cohort of patients with juvenile idiopathic arthritis (JIA). Methods Patients selected were those enrolled in an inception cohort study of JIA, the Research in Arthritis in Canadian Children Emphasizing Outcomes Study, within 6 months after diagnosis. The juvenile rheumatoid arthritis core criteria set and quality of life measures were collected at enrollment and 6 months later. Outcomes evaluated included inactive disease, Juvenile Arthritis Quality of Life Questionnaire (JAQQ) scores, and Childhood Health Assessment Questionnaire (C‐HAQ) scores at 6 months. Results Thirty‐three percent of patients had inactive disease at 6 months. Onset subtype and most baseline core criteria set measures correlated with all 3 outcomes. Relative to oligoarticular JIA, the risks of inactive disease were lower for enthesitis‐related arthritis, polyarthritis rheumatoid factor (RF)–negative JIA, and polyarthritis RF‐positive JIA, and were similar for psoriatic arthritis. In multiple regression analyses, the baseline JAQQ score was an independent predictor of all 3 outcomes. Other independent baseline predictors included polyarthritis RF‐negative and systemic JIA for inactive disease; C‐HAQ score and polyarthritis RF‐positive JIA for the 6‐month C‐HAQ score; and active joint count, pain, and time to diagnosis for the 6‐month JAQQ score. Conclusion Clinical measures soon after diagnosis predict short‐term outcomes for patients with JIA. The JAQQ is a predictor of multiple outcomes. Time to diagnosis affects quality of life in the short term.