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Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia

2010; Elsevier BV; Volume: 197; Issue: 2 Linguagem: Inglês

10.1016/j.cancergencyto.2009.11.008

1873-4456

Soo‐Mee Bang, Ji-Weon Seo, Kyoung Un Park, Seok Jin Kim, Kihyun Kım, Sun‐Hee Kim, Sung Ran Cho, Hugh C. Kim, Jaewoo Song, Jin Seok Kim, Kyung-Hee Kim, Jae Hoon Lee, Je‐Jung Lee, Myung‐Geun Shin, Cheolwon Suh, Hyun Sook, Doyeun Oh, Jong-Ho Won, Hyo Jung Kim, Sung‐Soo Yoon, Dong Soon Lee,

Chronic Myeloid Leukemia Treatments

To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.