Alleles 308A and 238A in the Tumor Necrosis Factor Alpha Gene Promoter Do Not Increase the Risk of Severe Malaria in Children with Plasmodium falciparum Infection in Mali
2006; American Society for Microbiology; Volume: 74; Issue: 12 Linguagem: Inglês
10.1128/iai.01581-05
ISSN1098-5522
AutoresSandrine Cabantous, Ogobara K. Doumbo, Stéphane Ranque, Belco Poudiougou, Abdoulaye Traoré, Xunya Hou, Marouf M. Keita, Mahamadou B. Cissé, Alain Dessein, Sandrine Marquet,
Tópico(s)Parasites and Host Interactions
ResumoABSTRACT The hypothesis that tumor necrosis factor (TNF) aggravates malaria in children is supported by observations that TNF polymorphisms and high TNF levels have been associated with cerebral malaria. Nevertheless, severe malaria was not associated with polymorphisms located at positions −308A and −238A in the TNF alpha gene promoter or with a high TNF level in plasma in children from Bamako, Mali.
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