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The Sharpless Asymmetric Aminohydroxylation of Olefins

1996; Wiley; Volume: 35; Issue: 12 Linguagem: Inglês

10.1002/anie.199613081

1521-3773

Oliver Reiser,

Asymmetric Hydrogenation and Catalysis

A dream became reality: Twenty years after the discovery of the basic process, Sharpless et al. have developed a catalytic asymmetric aminohydroxylation (AA) of alkenes. This reaction [Eq. (a)] provides an access to such important molecules as amino alcohols and α-hydroxy-β-amino acids in enantiomerically pure form.