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Synthesis of isogranulatimides A and B analogues possessing a 7-azaindole unit instead of an indole moiety

2003; Elsevier BV; Volume: 44; Issue: 24 Linguagem: Inglês

10.1016/s0040-4039(03)00924-9

1873-3581

Bernadette Hugon, Bruno Pfeiffer, Pierre Renard, Michelle Prudhomme,

Cancer therapeutics and mechanisms

The synthesis of a new family of isogranulatimides analogues is described in which a 7-azaindole replaces the indole moiety. The key step is the photocyclization of the aza didemnimide intermediates which leads to two isomeric analogues of isogranulatimides A and B. A derivative bearing a carbohydrate part linked to the azaindole via a β-N-glycosidic bond was also prepared.