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BIBTEX RIS

Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs

2013; Oxford University Press; Volume: 105; Issue: 17 Linguagem: Inglês

10.1093/jnci/djt168

ISSN

1460-2105

Autores

Bakhos A. Tannous, Mariam Kerami, Petra M. van der Stoop, Nicholas Kwiatkowski, Jinhua Wang, Wenjun Zhou, Almuth F. Keßler, Grant K. Lewandrowski, Lotte Hiddingh, Nik Sol, Tonny Lagerweij, Laurine E. Wedekind, Johanna M. Niers, Marco Barazas, R. Jonas A. Nilsson, Dirk Geerts, Philip C. De Witt Hamer, Carsten Hagemann, W. Peter Vandertop, Olaf van Tellingen, David P. Noske, Nathanael S. Gray, Thomas Würdinger,

Tópico(s)

DNA Repair Mechanisms

Resumo

BackgroundGlioblastomas exhibit a high level of chemotherapeutic resistance, including to the antimitotic agents vincristine and taxol. During the mitotic agent-induced arrest, glioblastoma cells are able to perform damage-control and self-repair to continue proliferation. Monopolar spindle 1 (MPS1/TTK) is a checkpoint kinase and a gatekeeper of the mitotic arrest.

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