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Highly Recyclable Chemo‐/Biocatalyzed Cascade Reactions with Ionic Liquids: One‐Pot Synthesis of Chiral Biaryl Alcohols

2010; Wiley; Volume: 16; Issue: 23 Linguagem: Inglês

10.1002/chem.201000302

1521-3765

Vincent Gauchot, Wolfgang Kroutil, Andreea R. Schmitzer,

Oxidative Organic Chemistry Reactions

Chemistry – A European JournalVolume 16, Issue 23 p. 6748-6751 Communication Highly Recyclable Chemo-/Biocatalyzed Cascade Reactions with Ionic Liquids: One-Pot Synthesis of Chiral Biaryl Alcohols Vincent Gauchot, Vincent Gauchot Department of Chemistry, Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586Search for more papers by this authorWolfgang Kroutil Prof. Dr., Wolfgang Kroutil Prof. Dr. Department of Chemistry, Organic and Bioorganic Chemistry University of Graz, Heinrichstrasse 28, 8010 Graz (Austria)Search for more papers by this authorAndreea R. Schmitzer Prof. Dr., Andreea R. Schmitzer Prof. Dr. [email protected] Department of Chemistry, Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586Search for more papers by this author Vincent Gauchot, Vincent Gauchot Department of Chemistry, Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586Search for more papers by this authorWolfgang Kroutil Prof. Dr., Wolfgang Kroutil Prof. Dr. Department of Chemistry, Organic and Bioorganic Chemistry University of Graz, Heinrichstrasse 28, 8010 Graz (Austria)Search for more papers by this authorAndreea R. Schmitzer Prof. Dr., Andreea R. Schmitzer Prof. Dr. [email protected] Department of Chemistry, Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586Search for more papers by this author First published: 14 June 2010 https://doi.org/10.1002/chem.201000302Citations: 76Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Mix and match: We report a cascade reaction sequence for the highly enantio- and diastereoselective synthesis of biaryl alcohols, employing a Suzuki coupling followed by a biocatalytic reduction in a biphasic system containing ionic liquids (ILs; see figure). We demonstrate the recyclability of the IL phase as well as the aqueous phase up to four cycles with only a negligible deactivation of reactivity and selectivity. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description chem_201000302_sm_miscellaneous_information.pdf65.4 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume16, Issue23June 18, 2010Pages 6748-6751 RelatedInformation