Initial Clinical Results of Tenecteplase (TNK) in Catheter-Directed Thrombolytic Therapy
2002; SAGE Publishing; Volume: 9; Issue: 5 Linguagem: Inglês
10.1583/1545-1550(2002)009 2.0.co;2
ISSN1545-1550
AutoresMahmood K. Razavi, Humberto Wong, Stephen T. Kee, Daniel Y. Sze, Charles P. Semba, Michael D. Dake,
Tópico(s)Diagnosis and Treatment of Venous Diseases
ResumoPurpose:To investigate the safety and immediate efficacy of 2 different doses of tenecteplase (TNK) in peripheral catheter-directed thrombolytic therapy of arterial occlusions and deep vein thrombosis (DVT).Methods:Over a 20-month period, 63 nonconsecutive patients underwent catheter-directed thrombolytic therapy with either 0.25 mg/h or 0.50 mg/h of TNK in a nonrandomized, open-label study. Of these, 55 patients (60 limbs) were treated for DVT (36 limbs in 16 men and 15 women; mean age 41 years, range 21–73) or peripheral arterial occlusions (24 limbs in 16 men and 8 women; mean age 63 years, range 32–91). The primary endpoints were major bleeding complications and angiographic reduction in clot burden.Results:The mean duration of infusion was 18 ± 4 hours in patients with arterial occlusions and 30 ± 13 in those with DVT. Twenty-one (87.5%) patients with occlusive disease had marked or complete lysis of clot. Thirty (83.3%) limbs with DVT had either marked or complete resolution of thrombus. There were ...
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