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CORPOREAL VENO-OCCLUSIVE DYSFUNCTION: A DISTAL ARTERIAL PATHOLOGY?

1998; Lippincott Williams & Wilkins; Volume: 160; Issue: 6 Part 1 Linguagem: Inglês

10.1016/s0022-5347(01)62241-9

1527-3792

Eric Wespes, Gil Raviv, Juan Pablo Vanegas, Christine Decaestecker, Michel Pétein, André Danguy, Claude C. Schulman, Róbert Kiss,

Prostate Cancer Diagnosis and Treatment

No AccessJournal of UrologyClinical Urology: Original Articles1 Dec 1998CORPOREAL VENO-OCCLUSIVE DYSFUNCTION: A DISTAL ARTERIAL PATHOLOGY? E. WESPES, G. RAVIV, J.-P. VANEGAS, C. DECAESTECKER, M. PETEIN, A. DANGUY, C.C. SCHULMAN, and R. KISS E. WESPESE. WESPES More articles by this author , G. RAVIVG. RAVIV More articles by this author , J.-P. VANEGASJ.-P. VANEGAS More articles by this author , C. DECAESTECKERC. DECAESTECKER More articles by this author , M. PETEINM. PETEIN More articles by this author , A. DANGUYA. DANGUY More articles by this author , C.C. SCHULMANC.C. SCHULMAN More articles by this author , and R. KISSR. KISS More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62241-9AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Alteration of intracavernous smooth muscle cells has been demonstrated in patients with pure venous leakage. This modification seems correlated with reduction of intracavernous oxygen tension. However, Doppler imaging of the cavernous arteries in these patients is normal. To understand the ischemic factor we studied the endothelium of the terminal arteries with computerized image analysis and immunohistochemical staining with 2 types of lectin in patients with venous leakage and those with normal erections. Lectins are glycoproteins that can be used as histological markers to monitor functional and pathological changes. Materials and Methods: Four patients 44 to 59 years old with normal erections who were operated on for penile cancer and 11 patients 27 to 62 years old with pure venous leakage (flow to maintain erection greater than 15 ml. per minute and cavernous flow velocity greater than 35 cm. per second) were included in the study. Immunohistochemical staining with 2 lectins, wheat germ agglutinin and Ulex europeaus agglutinin I, was performed and analyzed with computerized image analysis. The labeling index which relates to the percentage of staining indicates the distribution of the endothelial cells, and mean optical density which relates to the staining intensity indicates the function of these cells. Results: Mean labeling index values for the 2 lectins were similar in both groups (p >0.05). Mean optical density values for the 2 lectins were significantly greater for the patients with normal erections (p <0.01). Therefore, the distribution of the endothelial cells was the same while their function was different in patients with corporeal veno-occlusive dysfunction. Conclusions: Staining with wheat germ agglutinin and Ulex europeaus agglutinin I lectin types allowed us to detect alteration in the glyco-histochemistry of the endothelial cells of the small arteries, and venous leakage could be the first step in vasculogenic impotence. References 1 : Impotence. New Engl. J. Med.1989; 321: 164. Google Scholar 2 : Venous impotence: pathophysiology, diagnosis and treatment. J. Urol.1993; 149: 1238. Link, Google Scholar 3 : Correlation of altered penile ultrastructure with clinical arterial evaluation. J. Urol.1989; 142: 1462. Link, Google Scholar 4 : Corpora cavernosa ultrastructure in vascular erectile dysfunction. J. Urol.1990; 143: 1131. Link, Google Scholar 5 : Ultrastructural changes in impotent penile tissue: a comparison of 65 patients. J. Urol.1991; 145: 749. Link, Google Scholar 6 : Cavernous oxygen tension and smooth muscle fibers: relation and function. J. Urol.1995; 154: 1736. 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Google Scholar From the Departments of Urology and Pathology, Erasme Hospital, and Laboratory of Histology, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium, and Department of Urology, Centre Hospitals-Universitaire Charleroi, Charleroi, Belgium© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byWESPES E, WILDSCHUTZ T, ROUMEGUERE T and SCHULMAN C (2018) The Place of Surgery for Vascular Impotence in the Third MillenniumJournal of Urology, VOL. 170, NO. 4 Part 1, (1284-1286), Online publication date: 1-Oct-2003. Volume 160Issue 6 Part 1December 1998Page: 2054-2057 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information E. WESPES More articles by this author G. RAVIV More articles by this author J.-P. VANEGAS More articles by this author C. DECAESTECKER More articles by this author M. PETEIN More articles by this author A. DANGUY More articles by this author C.C. SCHULMAN More articles by this author R. KISS More articles by this author Expand All Advertisement PDF downloadLoading ...