Antifungal activity of itraconazole compared with hydroxy-itraconazole in vitro
2000; Oxford University Press; Volume: 45; Issue: 3 Linguagem: Inglês
10.1093/jac/45.3.371
ISSN1460-2091
AutoresFrank C. Odds, H. Vanden Bossche,
Tópico(s)Nail Diseases and Treatments
ResumoMicrobroth dilution tests in vitro showed the same IC50 values for itraconazole and hydroxy-itraconazole, within a mode ± one dilution range of experimental error, for 90% of 1481 isolates of pathogenic fungi, representing 48 genera. Some 10–15% of Candida glabrata and Trichophyton mentagrophytes isolates were more susceptible to itraconazole than hydroxy-itraconazole. Replicate tests with bioassay marker strains of Candida kefyr and Candida albicans showed no susceptibility variations outside the mode ± one dilution range. We conclude that few fungi differ substantially in their susceptibility to itraconazole and hydroxy-itraconazole.
Referência(s)