FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH
1986; Elsevier BV; Volume: 328; Issue: 8499 Linguagem: Inglês
10.1016/s0140-6736(86)91944-6
ISSN1474-547X
AutoresJohnD Clemens, Jeffrey R. Harris, M. R. Khan, BradfordA. Kay, Mohammad Yunus, Ann–Mari Svennerholm, DavidA. Sack, J. Chakraborty, BonitaF Stanton, Muhammad Umer Khan, William Atkinson, Jan Holmgren,
Tópico(s)Hepatitis Viruses Studies and Epidemiology
ResumoThe protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p<0·0001), and 11 cases in the WC group (protective efficacy 58%; p 10 years) and for different severities of cholera.
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