Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Sonobreast: Predicting Individualized Probabilities of Malignancy in Solid Breast Masses with Echographic Expression

2011; Wiley; Volume: 17; Issue: 2 Linguagem: Inglês

10.1111/j.1524-4741.2010.01046.x

1524-4741

Régis Resende Paulinelli, Ruffo Freitas‐Júnior, Clécio Ênio Murta de Lucena, Marise Amaral Rebouças Moreira, Vardeli Alves de Moraes, Júlio R. M. Bernardes-Junior, Célio da Silva Rocha Vidal, Alessandro Naldi Ruiz, Miliana Tostes Lucato, Nayara Gomes Silveira da Costa, Danilo Augusto Teixeira,

AI in cancer detection

Abstract: To create an individualized predictive tool for the risk of malignancy in solid breast masses, based on echographic and clinical characteristics. Research Ethics Committee approval and informed consent were obtained. This multi-center study included 1,403 solid breast masses prospectively. Each ultrasound feature was analyzed and compared with the definitive diagnosis. The ultrasound results, women's ages and family histories of breast cancer were included in a multivariate logistic regression model. Among the 1,403 lesions included in the study, 1,390 (99.1%) had a conclusive diagnosis: 343 malignant tumors (24.7%), and 1,047 benign masses (75.3%). The odds ratio (and confidence interval) for breast malignancy for each variable included in the model, as calculated by multivariate analysis, were as follows: irregular shape/noncircumscribed margins, 16.02 (7.75–33.09); heterogeneous echo texture, 4.50 (2.42–8.23); vertical orientation (not parallel to the skin), 2.23 (1.04–4.75); anterior echogenic rim, 2.62 (1.09–6.31); posterior shadowing, 2.38 (1.23–4.62); age more than 40 years, 2.19 (1.26–3.81); positive first-degree family history (mother, sister or daughter), 7.50 (2.65–21.18). There was no advantage in including the presence of internal vascularity, presence of thickened Cooper's ligaments or size of the mass, in the model. The predictive tool was named SONOBREAST and it is freely available for medical purposes on the internet site: http://www.sonobreast.com. The probability of malignancy in breast masses can be specified based on their ultrasound features, the woman's age and the family history of breast cancer.