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Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease

2009; Oxford University Press; Volume: 25; Issue: 4 Linguagem: Inglês

10.1093/ndt/gfp592

1460-2385

Sophie Liabeuf, Daniela V. Barreto, Fellype Carvalho Barreto, Natalie Meert, Griet Glorieux, Eva Schepers, M. Temmar, Gabriel Choukroun, Raymond Vanholder, Ziad A. Massy,

Electrolyte and hormonal disorders

Background. Uraemic toxins are considered to be emerging mortality risk factors in chronic kidney disease (CKD) patients. p-Cresol (a prototype protein-bound uraemic retention solute) has been shown to exert toxic effects in vitro. Recently, it has been demonstrated that p-cresol is present in plasma as its sulphate conjugate, p-cresylsulphate. The present study evaluated the distribution of free and total p-cresylsulphate and sought to determine whether these parameters were associated with vascular calcification, arterial stiffness and mortality risk in a cohort of CKD patients.