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The genome and transcriptome of Haemonchus contortus, a key model parasite for drug and vaccine discovery

2013; BioMed Central; Volume: 14; Issue: 8 Linguagem: Inglês

10.1186/gb-2013-14-8-r88

1474-760X

Roz Laing, Taisei Kikuchi, Axel Martinelli, Isheng Jason Tsai, Robin N. Beech, Elizabeth Redman, Nancy Holroyd, David J. Bartley, Helen Beasley, Collette Britton, David Curran, Eileen Devaney, Aude Gilabert, Martin Hunt, F. Jackson, Stephanie L Johnston, Ivan Kryukov, Keyu Li, Alison Morrison, Adam J. Reid, Neil Sargison, Gary Saunders, James D. Wasmuth, Adrian J. Wolstenholme, Matthew Berriman, John S. Gilleard, James A. Cotton,

Parasite Biology and Host Interactions

The small ruminant parasite Haemonchus contortus is the most widely used parasitic nematode in drug discovery, vaccine development and anthelmintic resistance research. Its remarkable propensity to develop resistance threatens the viability of the sheep industry in many regions of the world and provides a cautionary example of the effect of mass drug administration to control parasitic nematodes. Its phylogenetic position makes it particularly well placed for comparison with the free-living nematode Caenorhabditis elegans and the most economically important parasites of livestock and humans.