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Concise total synthesis of the aporphine alkaloid 7,7′-bisdehydro-O-methylisopiline by an InCl 3 mediated cycloisomerization reaction

2003; Royal Society of Chemistry; Issue: 17 Linguagem: Inglês

10.1039/b306880c

1364-548X

Alois Fürstner, Victor Mamane,

Phytochemical compounds biological activities

A novel InCl3 mediated cycloisomerization reaction leading to 10-halophenanthrene derivatives constitutes the key step of the first total syntheses of O-methyldehydroisopiline 10 and 7,7'-bisdehydro-O-methylisopiline 11, two prototype members of the aporphine family of alkaloids.