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Organochlorine compounds in urban fertile and infertile women

2009; Elsevier BV; Volume: 92; Issue: 3 Linguagem: Inglês

10.1016/j.fertnstert.2009.07.1212

1556-5653

Ana Marcia Xavier Bastos, María do Carmo Borges de Souza, G.L. Almeida Filho, T Krauß, Thelma Pavesi, L.E. Silva,

Toxic Organic Pollutants Impact

OBJECTIVE: The aim of this study was to identify and to quantify the levels of organochlorine compounds in an urban infertile women group compared to fertile ones trying to detect endocrine disruptor effects. DESIGN: case-control study MATERIALS AND METHODS: We studied women looking for infertility treatment (study group: n=15) and those that spontaneously became pregnant (control group: n=21).Blood samples were obtained to quantify the levels of serum concentrations of diclorodifeniltricloroetano (DDT), diclorodifeniltricloroetileno (DDE), hexaclorobenzeno (CCB) and polychlorinated biphenyls (PCBs 138, 153 and 180) through capillary gas chromatography. In the study group serum levels of progesterone was measured. RESULTS: The organochlorine pp DDE, the main metabolite of DDT was detected in 100% (15/15) of women in the study group and in 95.3% (20/21) of control group with significant difference (p=0,001). The PCBs 138,153 and 180,detected in all patients of the study group, had a negative correlation with the progesterone levels. In the control group the congeners 138 and 153 were detected in 85.7% (18/21) of the patients while the 180 was detected in 71.4% (15/21), (Table 1). The main etiology for infertility were: 33.3% of tubal factor, 20% of ovulatory dysfunction and 20% of both tubal and ovarian.Table 1Levels of organochlorine analyzedOrganochlorinenControl GroupnStudy GroupPesticides HCB70.09±0.1070.20±0.37 ppDDE200.88±0.81153.02±3.57 ppDDT50.66±0.1429.12±11.88PCBs 138180.06±0.08150.07±0.07 153180.07±0.06150.07±0.05 180150.07±0.05150.08±0.06Values are expreseed as mean ± DP Open table in a new tab Values are expreseed as mean ± DP CONCLUSIONS: The urban population is exposed to the most prevalent organochlorine compounds. Our results suggest a negative correlation between the presence of organochlorine and the plasma levels of progesterone.